BRD-K42489623_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K42489623_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASPN asporin
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CD200 CD200 molecule
CD300A CD300a molecule
CD36 CD36 molecule (thrombospondin receptor)
CD8A CD8a molecule
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECM1 extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FRZB frizzled-related protein
GCLM glutamate-cysteine ligase, modifier subunit
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGKV1-5 immunoglobulin kappa variable 1-5
LYPD3 LY6/PLAUR domain containing 3
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTSS1 metastasis suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLEK2 pleckstrin 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
TCP1 t-complex 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
COL5A1 collagen, type V, alpha 1
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DMD dystrophin
EFNB2 ephrin-B2
EHD1 EH-domain containing 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ERAP2 endoplasmic reticulum aminopeptidase 2
F2R coagulation factor II (thrombin) receptor
FLNA filamin A, alpha
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HOXA5 homeobox A5
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
KLF10 Kruppel-like factor 10
LITAF lipopolysaccharide-induced TNF factor
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MT1X metallothionein 1X
MT2A metallothionein 2A
NOTCH2 notch 2
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTCH1 patched 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNASE3 ribonuclease, RNase A family, 3
RPS26 ribosomal protein S26
SDC2 syndecan 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRIB2 tribbles pseudokinase 2
TTC3 tetratricopeptide repeat domain 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta