BRD-K42452249_EO 1428_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K42452249_EO 1428_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXPH5 exophilin 5
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS6 growth arrest-specific 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSDMB gasdermin B
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IPO13 importin 13
IRS2 insulin receptor substrate 2
ITM2C integral membrane protein 2C
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP7 matrix metallopeptidase 7
MSLN mesothelin
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
PAPD7 PAP associated domain containing 7
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PON3 paraoxonase 3
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RCAN2 regulator of calcineurin 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA5 annexin A5
ARMCX6 armadillo repeat containing, X-linked 6
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP22 dual specificity phosphatase 22
FAM46A family with sequence similarity 46, member A
FKBP14 FK506 binding protein 14, 22 kDa
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPB11 heat shock protein family B (small), member 11
IL6ST interleukin 6 signal transducer
LAGE3 L antigen family, member 3
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA5 melanoma antigen family A5
MAGEA6 melanoma antigen family A6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MSX1 msh homeobox 1
NFIB nuclear factor I/B
PI3 peptidase inhibitor 3, skin-derived
PLSCR3 phospholipid scramblase 3
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
SACS sacsin molecular chaperone
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
VCAM1 vascular cell adhesion molecule 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZEB2 zinc finger E-box binding homeobox 2