BRD-K42436189_AZ20_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K42436189_AZ20_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ALDOB aldolase B, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCAS3 breast carcinoma amplified sequence 3
BLNK B-cell linker
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CLDN4 claudin 4
CRYAB crystallin, alpha B
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GMPR guanosine monophosphate reductase
GPR137B G protein-coupled receptor 137B
GRAMD3 GRAM domain containing 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LY75 lymphocyte antigen 75
MBNL2 muscleblind-like splicing regulator 2
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
NFIB nuclear factor I/B
OLFM4 olfactomedin 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA1A phospholipase A1 member A
RAB29 RAB29, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SP100 SP100 nuclear antigen
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STON1 stonin 1
TFF1 trefoil factor 1
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
VDAC1 voltage-dependent anion channel 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AUTS2 autism susceptibility candidate 2
C3 complement component 3
CA12 carbonic anhydrase XII
CCNE2 cyclin E2
CDC6 cell division cycle 6
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL5 chemokine (C-X-C motif) ligand 5
FEN1 flap structure-specific endonuclease 1
FGG fibrinogen gamma chain
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HMGB2 high mobility group box 2
HOXC10 homeobox C10
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KRT6A keratin 6A, type II
LDHB lactate dehydrogenase B
LTF lactotransferrin
MCM4 minichromosome maintenance complex component 4
MFSD10 major facilitator superfamily domain containing 10
MUC4 mucin 4, cell surface associated
NNMT nicotinamide N-methyltransferase
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SPA17 sperm autoantigenic protein 17
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TF transferrin
TMEM176B transmembrane protein 176B
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
USP22 ubiquitin specific peptidase 22