BRD-K42191735_buparlisib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K42191735_buparlisib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASS1 argininosuccinate synthase 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFB complement factor B
CHRDL1 chordin-like 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL13 chemokine (C-X-C motif) ligand 13
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
IRS2 insulin receptor substrate 2
LAMP1 lysosomal-associated membrane protein 1
LGALS8 lectin, galactoside-binding, soluble, 8
MSLN mesothelin
NEFM neurofilament, medium polypeptide
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PPAP2B phosphatidic acid phosphatase type 2B
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TSPAN4 tetraspanin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOB apolipoprotein B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCP110 centriolar coiled coil protein 110kDa
CD24 CD24 molecule
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSC2 desmocollin 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
EREG epiregulin
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GPER1 G protein-coupled estrogen receptor 1
HEPH hephaestin
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
MOCOS molybdenum cofactor sulfurase
NLGN4X neuroligin 4, X-linked
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RPP38 ribonuclease P/MRP 38kDa subunit
S100A8 S100 calcium binding protein A8
SESN1 sestrin 1
STK17A serine/threonine kinase 17a
STK26 serine/threonine protein kinase 26
TUBB6 tubulin, beta 6 class V