BRD-K42191735_buparlisib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K42191735_buparlisib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ARID4B AT rich interactive domain 4B (RBP1-like)
BCL6 B-cell CLL/lymphoma 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DLK1 delta-like 1 homolog (Drosophila)
EMP2 epithelial membrane protein 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBP1 fructose-1,6-bisphosphatase 1
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
METTL7A methyltransferase like 7A
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPAP2B phosphatidic acid phosphatase type 2B
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYNE2 spectrin repeat containing, nuclear envelope 2
TBXA2R thromboxane A2 receptor
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
CCND1 cyclin D1
CCND2 cyclin D2
CLC Charcot-Leyden crystal galectin
CXCL8 chemokine (C-X-C motif) ligand 8
ELANE elastase, neutrophil expressed
EPHA3 EPH receptor A3
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLK10 kallikrein-related peptidase 10
KRT6A keratin 6A, type II
LCN2 lipocalin 2
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MID1IP1 MID1 interacting protein 1
MSMO1 methylsterol monooxygenase 1
NAV3 neuron navigator 3
NGRN neugrin, neurite outgrowth associated
ODC1 ornithine decarboxylase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SPRR3 small proline-rich protein 3
TFRC transferrin receptor
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
WSB2 WD repeat and SOCS box containing 2
ZBED2 zinc finger, BED-type containing 2
ZDHHC6 zinc finger, DHHC-type containing 6