BRD-K42191735_buparlisib_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K42191735_buparlisib_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AMDHD2 amidohydrolase domain containing 2
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DPP8 dipeptidyl-peptidase 8
EMX2 empty spiracles homeobox 2
EPHA3 EPH receptor A3
ETV1 ets variant 1
FOXN3 forkhead box N3
GRAMD3 GRAM domain containing 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HOMER2 homer scaffolding protein 2
HOXA5 homeobox A5
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGKV4-1 immunoglobulin kappa variable 4-1
ISG15 ISG15 ubiquitin-like modifier
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
LAMP2 lysosomal-associated membrane protein 2
LYPD1 LY6/PLAUR domain containing 1
MEF2C myocyte enhancer factor 2C
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NOTCH2NL notch 2 N-terminal like
RBM47 RNA binding motif protein 47
SIDT2 SID1 transmembrane family, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB2 tribbles pseudokinase 2
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BEX1 brain expressed, X-linked 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCND1 cyclin D1
CD24 CD24 molecule
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HIST1H4C histone cluster 1, H4c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
KRT18 keratin 18, type I
L1CAM L1 cell adhesion molecule
LYZ lysozyme
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
OLFM1 olfactomedin 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTPRC protein tyrosine phosphatase, receptor type, C
RELN reelin
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A11 S100 calcium binding protein A11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STMN2 stathmin 2
SYBU syntabulin (syntaxin-interacting)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TYROBP TYRO protein tyrosine kinase binding protein