BRD-K42191735_buparlisib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K42191735_buparlisib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIPOQ adiponectin, C1Q and collagen domain containing
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CLEC2B C-type lectin domain family 2, member B
CTGF connective tissue growth factor
CXCL9 chemokine (C-X-C motif) ligand 9
DDAH1 dimethylarginine dimethylaminohydrolase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGL1 fibrinogen-like 1
FST follistatin
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GPX2 glutathione peroxidase 2
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LYZ lysozyme
MLPH melanophilin
N4BP2L2 NEDD4 binding protein 2-like 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLIN1 perilipin 1
PPARG peroxisome proliferator-activated receptor gamma
RAB4A RAB4A, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIK1 salt-inducible kinase 1
SLC22A18 solute carrier family 22, member 18
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPDEF SAM pointed domain containing ETS transcription factor
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN4 tetraspanin 4
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AIM2 absent in melanoma 2
CADM1 cell adhesion molecule 1
CCNB2 cyclin B2
CLU clusterin
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
EPHA3 EPH receptor A3
FRZB frizzled-related protein
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI6 interferon, alpha-inducible protein 6
MALL mal, T-cell differentiation protein-like
NDNF neuron-derived neurotrophic factor
PENK proenkephalin
PLK1 polo-like kinase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPA1 replication protein A1, 70kDa
SST somatostatin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1