BRD-K42191735_buparlisib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K42191735_buparlisib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABLIM1 actin binding LIM protein 1
ALCAM activated leukocyte cell adhesion molecule
ARMCX2 armadillo repeat containing, X-linked 2
BEX1 brain expressed, X-linked 1
C3 complement component 3
CA12 carbonic anhydrase XII
CCDC92 coiled-coil domain containing 92
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLIP3 CAP-GLY domain containing linker protein 3
COL1A2 collagen, type I, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FN1 fibronectin 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
H1FX H1 histone family, member X
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
LGALS8 lectin, galactoside-binding, soluble, 8
LMO3 LIM domain only 3 (rhombotin-like 2)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MARCKSL1 MARCKS-like 1
MSLN mesothelin
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
OLFML2A olfactomedin-like 2A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PDE8B phosphodiesterase 8B
PDZK1IP1 PDZK1 interacting protein 1
PGLS 6-phosphogluconolactonase
POSTN periostin, osteoblast specific factor
QSOX1 quiescin Q6 sulfhydryl oxidase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
BCLAF1 BCL2-associated transcription factor 1
BLNK B-cell linker
CDC42 cell division cycle 42
COL15A1 collagen, type XV, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EREG epiregulin
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
NUTF2 nuclear transport factor 2
OAT ornithine aminotransferase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLAGL1 pleiomorphic adenoma gene-like 1
PPARG peroxisome proliferator-activated receptor gamma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RCAN1 regulator of calcineurin 1
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
TMPRSS2 transmembrane protease, serine 2
VCAN versican
ZEB2 zinc finger E-box binding homeobox 2