BRD-K42191735_buparlisib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K42191735_buparlisib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIDEB cell death-inducing DFFA-like effector b
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBN2 fibrillin 2
IDS iduronate 2-sulfatase
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MT1H metallothionein 1H
MYLK myosin light chain kinase
NBEA neurobeachin
NELL2 NEL-like 2 (chicken)
NVL nuclear VCP-like
PLSCR4 phospholipid scramblase 4
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PROM1 prominin 1
S100A8 S100 calcium binding protein A8
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SMA4 glucuronidase, beta pseudogene
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRG1 adhesion G protein-coupled receptor G1
ADRB2 adrenoceptor beta 2, surface
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM162A family with sequence similarity 162, member A
GARS glycyl-tRNA synthetase
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
HOMER1 homer scaffolding protein 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
MAGEA3 melanoma antigen family A3
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
NRN1 neuritin 1
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSAT1 phosphoserine aminotransferase 1
QPRT quinolinate phosphoribosyltransferase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
STC2 stanniocalcin 2
STK10 serine/threonine kinase 10
TARS threonyl-tRNA synthetase
TMED5 transmembrane emp24 protein transport domain containing 5
TPD52 tumor protein D52
YARS tyrosyl-tRNA synthetase