BRD-K42191735_buparlisib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K42191735_buparlisib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ANKRD10 ankyrin repeat domain 10
BRD8 bromodomain containing 8
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COLEC12 collectin sub-family member 12
CREBL2 cAMP responsive element binding protein-like 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DST dystonin
ERBB3 erb-b2 receptor tyrosine kinase 3
FZD6 frizzled class receptor 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GPR137B G protein-coupled receptor 137B
GRN granulin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
KLHDC2 kelch domain containing 2
LAMB1 laminin, beta 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
NBR1 neighbor of BRCA1 gene 1
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PLEKHA5 pleckstrin homology domain containing, family A member 5
RAB31 RAB31, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TXNIP thioredoxin interacting protein
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDC6 cell division cycle 6
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FAM57A family with sequence similarity 57, member A
G0S2 G0/G1 switch 2
GPI glucose-6-phosphate isomerase
HK2 hexokinase 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL13RA2 interleukin 13 receptor, alpha 2
LPL lipoprotein lipase
MALL mal, T-cell differentiation protein-like
MCM3 minichromosome maintenance complex component 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRPS12 mitochondrial ribosomal protein S12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PNP purine nucleoside phosphorylase
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SET SET nuclear proto-oncogene
SFN stratifin
SNRPE small nuclear ribonucleoprotein polypeptide E
STIP1 stress-induced phosphoprotein 1
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon