BRD-K42191735_buparlisib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K42191735_buparlisib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHRDL1 chordin-like 1
CRYAB crystallin, alpha B
CYBRD1 cytochrome b reductase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
LGALS4 lectin, galactoside-binding, soluble, 4
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH1 notch 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PNMAL1 paraneoplastic Ma antigen family-like 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTX3 pentraxin 3, long
RB1CC1 RB1-inducible coiled-coil 1
REG1A regenerating islet-derived 1 alpha
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SOX9 SRY (sex determining region Y)-box 9
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TPM1 tropomyosin 1 (alpha)
UFM1 ubiquitin-fold modifier 1
VNN1 vanin 1
ZMAT3 zinc finger, matrin-type 3
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDK1 cyclin-dependent kinase 1
CRABP2 cellular retinoic acid binding protein 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
HBB hemoglobin, beta
IL1R1 interleukin 1 receptor, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC17 leucine rich repeat containing 17
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
PCP4 Purkinje cell protein 4
PGM1 phosphoglucomutase 1
PLAT plasminogen activator, tissue
PRKD3 protein kinase D3
RBP1 retinol binding protein 1, cellular
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SQRDL sulfide quinone reductase-like (yeast)
TACSTD2 tumor-associated calcium signal transducer 2
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)