BRD-K42098891_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K42098891_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKS2 CDC28 protein kinase regulatory subunit 2
CRIP1 cysteine-rich protein 1 (intestinal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBP emopamil binding protein (sterol isomerase)
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0753 KIAA0753
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LY75 lymphocyte antigen 75
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MBNL1 muscleblind-like splicing regulator 1
MRPS30 mitochondrial ribosomal protein S30
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
PCDH9 protocadherin 9
PLS1 plastin 1
POU2AF1 POU class 2 associating factor 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
XK X-linked Kx blood group

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
BCHE butyrylcholinesterase
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
CRISP3 cysteine-rich secretory protein 3
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FILIP1L filamin A interacting protein 1-like
FPGS folylpolyglutamate synthase
GJA1 gap junction protein, alpha 1, 43kDa
HCAR3 hydroxycarboxylic acid receptor 3
IGFBP5 insulin-like growth factor binding protein 5
LCN2 lipocalin 2
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NXN nucleoredoxin
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPL periplakin
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PXDN peroxidasin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX11 SRY (sex determining region Y)-box 11
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
TCEA2 transcription elongation factor A (SII), 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
WASF1 WAS protein family, member 1
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)