BRD-K42021584_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

27 genes differentially expressed following the BRD-K42021584_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND2 cyclin D2
CHEK2 checkpoint kinase 2
CXADR coxsackie virus and adenovirus receptor
EGR2 early growth response 2
GATA6 GATA binding protein 6
IGFBP3 insulin-like growth factor binding protein 3
LIN28A lin-28 homolog A (C. elegans)
NANOG Nanog homeobox
NDN necdin, melanoma antigen (MAGE) family member
OLFM4 olfactomedin 4
PRSS2 protease, serine, 2 (trypsin 2)
PSD3 pleckstrin and Sec7 domain containing 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
BID BH3 interacting domain death agonist
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
GLRX glutaredoxin (thioltransferase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
NQO1 NAD(P)H dehydrogenase, quinone 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SQLE squalene epoxidase
TXNL4B thioredoxin-like 4B