BRD-K41895714_AS-605240_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K41895714_AS-605240_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMOTL2 angiomotin like 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCAM basal cell adhesion molecule (Lutheran blood group)
C9ORF3 chromosome 9 open reading frame 3
CD53 CD53 molecule
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
DAAM1 dishevelled associated activator of morphogenesis 1
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FERMT2 fermitin family member 2
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
HACD1 3-hydroxyacyl-CoA dehydratase 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LMCD1 LIM and cysteine-rich domains 1
LPL lipoprotein lipase
LYPD1 LY6/PLAUR domain containing 1
MAGEA3 melanoma antigen family A3
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OXTR oxytocin receptor
PDLIM1 PDZ and LIM domain 1
PLS3 plastin 3
PODXL podocalyxin-like
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCI protein kinase C, iota
QKI QKI, KH domain containing, RNA binding
RBP1 retinol binding protein 1, cellular
RFTN1 raftlin, lipid raft linker 1
RPL37A ribosomal protein L37a
S100A10 S100 calcium binding protein A10
SAMD4A sterile alpha motif domain containing 4A
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX17 SRY (sex determining region Y)-box 17
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADGRG1 adhesion G protein-coupled receptor G1
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
GCLC glutamate-cysteine ligase, catalytic subunit
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLM1 golgi membrane protein 1
GSAP gamma-secretase activating protein
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HNMT histamine N-methyltransferase
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
LAT2 linker for activation of T cells family, member 2
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAV3 neuron navigator 3
NDRG2 NDRG family member 2
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCH protein kinase C, eta
PROM1 prominin 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOBTB3 Rho-related BTB domain containing 3
RTN1 reticulon 1
SLC16A6 solute carrier family 16, member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRI sorcin
STK39 serine threonine kinase 39
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein