BRD-K41895714_AS-605240_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K41895714_AS-605240_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BID BH3 interacting domain death agonist
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CD14 CD14 molecule
CD163 CD163 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN7 claudin 7
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GOLGA8B golgin A8 family, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HOXB6 homeobox B6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
MEOX2 mesenchyme homeobox 2
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL9 myosin, light chain 9, regulatory
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFD platelet derived growth factor D
PDZD2 PDZ domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PENK proenkephalin
PPL periplakin
PRDX2 peroxiredoxin 2
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPRR1B small proline-rich protein 1B
STEAP3 STEAP family member 3, metalloreductase
SYBU syntabulin (syntaxin-interacting)
TACC2 transforming, acidic coiled-coil containing protein 2
TAGLN transgelin
TCEAL4 transcription elongation factor A (SII)-like 4
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TMOD1 tropomodulin 1
TNS1 tensin 1
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
WDR7 WD repeat domain 7

decreased expression

Symbol Name
AIM2 absent in melanoma 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BASP1 brain abundant, membrane attached signal protein 1
BMP2 bone morphogenetic protein 2
CLEC2B C-type lectin domain family 2, member B
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HAS2 hyaluronan synthase 2
HHEX hematopoietically expressed homeobox
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MRPS2 mitochondrial ribosomal protein S2
NAV3 neuron navigator 3
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPARD peroxisome proliferator-activated receptor delta
PTN pleiotrophin
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
VIM vimentin
WARS tryptophanyl-tRNA synthetase
WWTR1 WW domain containing transcription regulator 1