BRD-K41895714_AS-605240_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K41895714_AS-605240_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAN aggrecan
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ALCAM activated leukocyte cell adhesion molecule
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C8ORF4 chromosome 8 open reading frame 4
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC3B C-type lectin domain family 3, member B
CNN1 calponin 1, basic, smooth muscle
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSZ cathepsin Z
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DUSP1 dual specificity phosphatase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENAH enabled homolog (Drosophila)
FAM117A family with sequence similarity 117, member A
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GPC4 glypican 4
GPER1 G protein-coupled estrogen receptor 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H2AC histone cluster 1, H2ac
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LMOD1 leiomodin 1 (smooth muscle)
MMP3 matrix metallopeptidase 3
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NDRG1 N-myc downstream regulated 1
NREP neuronal regeneration related protein
NXN nucleoredoxin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXTR oxytocin receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RHOQ ras homolog family member Q
RIT1 Ras-like without CAAX 1
SC5D sterol-C5-desaturase
SEPW1 selenoprotein W, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOCS2 suppressor of cytokine signaling 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK38L serine/threonine kinase 38 like
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA10 annexin A10
ASF1B anti-silencing function 1B histone chaperone
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL13A1 collagen, type XIII, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EPHA3 EPH receptor A3
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCTD12 potassium channel tetramerization domain containing 12
KIF1BP KIF1 binding protein
LAMB1 laminin, beta 1
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SLIT2 slit homolog 2 (Drosophila)
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TMEM100 transmembrane protein 100
TMEM194A transmembrane protein 194A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
ZFPM2 zinc finger protein, FOG family member 2
ZWINT ZW10 interacting kinetochore protein