BRD-K41895714_AS-605240_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K41895714_AS-605240_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
GATA3 GATA binding protein 3
GSTA4 glutathione S-transferase alpha 4
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NOV nephroblastoma overexpressed
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PRKCA protein kinase C, alpha
PTCH1 patched 1
PTGES prostaglandin E synthase
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
ANXA3 annexin A3
ASPH aspartate beta-hydroxylase
CA2 carbonic anhydrase II
CD200 CD200 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DUSP6 dual specificity phosphatase 6
EPHA2 EPH receptor A2
EREG epiregulin
EXOSC4 exosome component 4
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
H2AFZ H2A histone family, member Z
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INPP1 inositol polyphosphate-1-phosphatase
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
NID1 nidogen 1
NOP56 NOP56 ribonucleoprotein
OXA1L oxidase (cytochrome c) assembly 1-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase