BRD-K41895714_AS-605240_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K41895714_AS-605240_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BEX1 brain expressed, X-linked 1
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
COL9A2 collagen, type IX, alpha 2
GPNMB glycoprotein (transmembrane) nmb
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LITAF lipopolysaccharide-induced TNF factor
LYST lysosomal trafficking regulator
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PROM1 prominin 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNX10 sorting nexin 10
SPINK1 serine peptidase inhibitor, Kazal type 1
STK10 serine/threonine kinase 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TSPAN8 tetraspanin 8
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ASPH aspartate beta-hydroxylase
CCDC109B coiled-coil domain containing 109B
CCND1 cyclin D1
CEMIP cell migration inducing protein, hyaluronan binding
CTGF connective tissue growth factor
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAT1 FAT atypical cadherin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL2 four and a half LIM domains 2
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGKV4-1 immunoglobulin kappa variable 4-1
INPP1 inositol polyphosphate-1-phosphatase
KCTD12 potassium channel tetramerization domain containing 12
LAP3 leucine aminopeptidase 3
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LXN latexin
MMP9 matrix metallopeptidase 9
MYO6 myosin VI
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2B olfactomedin-like 2B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RHCG Rh family, C glycoprotein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STOM stomatin
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN4 tetraspanin 4
USP6NL USP6 N-terminal like
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3