BRD-K41895714_AS-605240_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

342 genes differentially expressed following the BRD-K41895714_AS-605240_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AUH AU RNA binding protein/enoyl-CoA hydratase
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
BTG2 BTG family, member 2
C14ORF159 chromosome 14 open reading frame 159
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CAPN3 calpain 3, (p94)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
COL21A1 collagen, type XXI, alpha 1
CRYAB crystallin, alpha B
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EPHA3 EPH receptor A3
FADS3 fatty acid desaturase 3
FAM63A family with sequence similarity 63, member A
FBLN1 fibulin 1
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GPC4 glypican 4
GPM6B glycoprotein M6B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HBP1 HMG-box transcription factor 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HOOK2 hook microtubule-tethering protein 2
HSPG2 heparan sulfate proteoglycan 2
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KIFAP3 kinesin-associated protein 3
KLHL24 kelch-like family member 24
LAMB2 laminin, beta 2 (laminin S)
LMBRD1 LMBR1 domain containing 1
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOV nephroblastoma overexpressed
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLP1 proteolipid protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RABAC1 Rab acceptor 1 (prenylated)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
ROGDI rogdi homolog (Drosophila)
RXRA retinoid X receptor, alpha
SCPEP1 serine carboxypeptidase 1
SCRG1 stimulator of chondrogenesis 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX2 SRY (sex determining region Y)-box 2
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SSBP2 single-stranded DNA binding protein 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNPO synaptopodin
THBS3 thrombospondin 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM135 transmembrane protein 135
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AGO2 argonaute RISC catalytic component 2
AGTR1 angiotensin II receptor, type 1
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL4A2 collagen, type IV, alpha 2
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV4 ets variant 4
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP4 GTP binding protein 4
GTSE1 G-2 and S-phase expressed 1
HBEGF heparin-binding EGF-like growth factor
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PBK PDZ binding kinase
PDLIM5 PDZ and LIM domain 5
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
RAD51 RAD51 recombinase
RCC1 regulator of chromosome condensation 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFWD3 ring finger and WD repeat domain 3
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SCML1 sex comb on midleg-like 1 (Drosophila)
SEH1L SEH1-like (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRM spermidine synthase
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN5 tetraspanin 5
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein