BRD-K41895714_AS-605240_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K41895714_AS-605240_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA4 annexin A4
APOD apolipoprotein D
ATF3 activating transcription factor 3
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C14ORF159 chromosome 14 open reading frame 159
C1RL complement component 1, r subcomponent-like
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFH complement factor H
CFI complement factor I
CRYAB crystallin, alpha B
CTSK cathepsin K
CTSO cathepsin O
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP1B FK506 binding protein 1B, 12.6 kDa
GBAS glioblastoma amplified sequence
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSTA4 glutathione S-transferase alpha 4
HIST1H2BD histone cluster 1, H2bd
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HMGN3 high mobility group nucleosomal binding domain 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
MAGEA3 melanoma antigen family A3
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RABAC1 Rab acceptor 1 (prenylated)
RABGAP1L RAB GTPase activating protein 1-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB1 Rho-related BTB domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSPAN31 tetraspanin 31
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AMD1 adenosylmethionine decarboxylase 1
ARG1 arginase 1
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
BCAR3 breast cancer anti-estrogen resistance 3
BOP1 block of proliferation 1
CCND1 cyclin D1
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CHGB chromogranin B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CST6 cystatin E/M
CTSZ cathepsin Z
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FJX1 four jointed box 1 (Drosophila)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
RCC1 regulator of chromosome condensation 1
RIMBP2 RIMS binding protein 2
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCEL sciellin
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1