BRD-K41859756_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K41859756_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AMDHD2 amidohydrolase domain containing 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL5A2 collagen, type V, alpha 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IL7R interleukin 7 receptor
INHBE inhibin, beta E
MUT methylmalonyl CoA mutase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUCB2 nucleobindin 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PON3 paraoxonase 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RHOB ras homolog family member B
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SPAG16 sperm associated antigen 16
TPR translocated promoter region, nuclear basket protein
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
CA1 carbonic anhydrase I
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EXOSC4 exosome component 4
FOSL1 FOS-like antigen 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA6 integrin, alpha 6
LEPR leptin receptor
MYH11 myosin, heavy chain 11, smooth muscle
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTDSS1 phosphatidylserine synthase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBP1 retinol binding protein 1, cellular
SPRED2 sprouty-related, EVH1 domain containing 2
TAC1 tachykinin, precursor 1
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TSPAN5 tetraspanin 5
UBE2S ubiquitin-conjugating enzyme E2S
ZFP36L2 ZFP36 ring finger protein-like 2