BRD-K41859756_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

151 genes differentially expressed following the BRD-K41859756_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ARF4 ADP-ribosylation factor 4
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
CALD1 caldesmon 1
CALR calreticulin
CALU calumenin
CANX calnexin
CAPN6 calpain 6
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CKAP4 cytoskeleton-associated protein 4
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DERL2 derlin 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EAF2 ELL associated factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
ERP29 endoplasmic reticulum protein 29
FAM114A1 family with sequence similarity 114, member A1
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLIM4 golgi integral membrane protein 4
GORASP2 golgi reassembly stacking protein 2, 55kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MLEC malectin
MYDGF myeloid-derived growth factor
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PERP PERP, TP53 apoptosis effector
PGM3 phosphoglucomutase 3
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAUR plasminogen activator, urokinase receptor
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRRC1 proline-rich coiled-coil 1
RAD9A RAD9 homolog A (S. pombe)
RRBP1 ribosome binding protein 1
SAR1B secretion associated, Ras related GTPase 1B
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEC61B Sec61 beta subunit
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPEN spen family transcriptional repressor
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SUCO SUN domain containing ossification factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM214 transmembrane protein 214
TMEM39A transmembrane protein 39A
TMEM45A transmembrane protein 45A
TXNDC15 thioredoxin domain containing 15
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBXN4 UBX domain protein 4
UFM1 ubiquitin-fold modifier 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
BAMBI BMP and activin membrane-bound inhibitor
C7 complement component 7
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNAS GNAS complex locus
IFITM1 interferon induced transmembrane protein 1
KYNU kynureninase
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OLFM1 olfactomedin 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
SMAD1 SMAD family member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
ZFP36L2 ZFP36 ring finger protein-like 2