BRD-K41859756_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

338 genes differentially expressed following the BRD-K41859756_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFF1 AF4/FMR2 family, member 1
AGRN agrin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKMY2 ankyrin repeat and MYND domain containing 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCL5 chemokine (C-C motif) ligand 5
CCNG1 cyclin G1
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CRYZ crystallin, zeta (quinone reductase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAZAP2 DAZ associated protein 2
DCN decorin
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DRAM1 DNA-damage regulated autophagy modulator 1
DYNLRB1 dynein, light chain, roadblock-type 1
EFCAB14 EF-hand calcium binding domain 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ELF5 E74-like factor 5 (ets domain transcription factor)
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FAM13A family with sequence similarity 13, member A
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GLRX glutaredoxin (thioltransferase)
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
INSR insulin receptor
ITGB5 integrin, beta 5
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LRRC41 leucine rich repeat containing 41
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MID1 midline 1
MINPP1 multiple inositol-polyphosphate phosphatase 1
MKRN1 makorin ring finger protein 1
MNDA myeloid cell nuclear differentiation antigen
MOB1A MOB kinase activator 1A
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NCOA2 nuclear receptor coactivator 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPC2 Niemann-Pick disease, type C2
NUCB2 nucleobindin 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PFKM phosphofructokinase, muscle
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PINK1 PTEN induced putative kinase 1
PIP prolactin-induced protein
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPRT quinolinate phosphoribosyltransferase
RAB5B RAB5B, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS27L ribosomal protein S27-like
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SRGN serglycin
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOM stomatin
SYT1 synaptotagmin I
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE4 transducin-like enhancer of split 4
TM9SF3 transmembrane 9 superfamily member 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
USP9X ubiquitin specific peptidase 9, X-linked
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADSL adenylosuccinate lyase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BOP1 block of proliferation 1
BYSL bystin-like
C11ORF24 chromosome 11 open reading frame 24
C1ORF116 chromosome 1 open reading frame 116
C1QBP complement component 1, q subcomponent binding protein
C20ORF27 chromosome 20 open reading frame 27
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBS cystathionine-beta-synthase
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD320 CD320 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKLF chemokine-like factor
DCTPP1 dCTP pyrophosphatase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DHFR dihydrofolate reductase
DPH2 DPH2 homolog (S. cerevisiae)
DSCC1 DNA replication and sister chromatid cohesion 1
EGR3 early growth response 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
EXOSC2 exosome component 2
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM173A family with sequence similarity 173, member A
FAM216A family with sequence similarity 216, member A
FAM86B1 family with sequence similarity 86, member B1
FASTKD3 FAST kinase domains 3
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
GALE UDP-galactose-4-epimerase
GARS glycyl-tRNA synthetase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GPM6A glycoprotein M6A
GREB1 growth regulation by estrogen in breast cancer 1
GTF3A general transcription factor IIIA
HBEGF heparin-binding EGF-like growth factor
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IPO4 importin 4
ISG15 ISG15 ubiquitin-like modifier
ITGB1BP1 integrin beta 1 binding protein 1
KLF4 Kruppel-like factor 4 (gut)
LAGE3 L antigen family, member 3
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
METRN meteorin, glial cell differentiation regulator
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL24 mitochondrial ribosomal protein L24
MRPL40 mitochondrial ribosomal protein L40
MRPL57 mitochondrial ribosomal protein L57
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NHP2 NHP2 ribonucleoprotein
NLE1 notchless homolog 1 (Drosophila)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT5 protein arginine methyltransferase 5
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
PYGL phosphorylase, glycogen, liver
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A2 S100 calcium binding protein A2
SCO2 SCO2 cytochrome c oxidase assembly protein
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SEPT9 septin 9
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STRA13 stimulated by retinoic acid 13
THY1 Thy-1 cell surface antigen
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM109 transmembrane protein 109
TMEM126B transmembrane protein 126B
TMEM223 transmembrane protein 223
TMX1 thioredoxin-related transmembrane protein 1
TRH thyrotropin-releasing hormone
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TXN thioredoxin
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UGDH UDP-glucose 6-dehydrogenase
WDR12 WD repeat domain 12
WDR74 WD repeat domain 74
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
ZNF593 zinc finger protein 593