BRD-K41859756_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K41859756_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA6 annexin A6
ARL1 ADP-ribosylation factor-like 1
BAG3 BCL2-associated athanogene 3
CANX calnexin
CAPN6 calpain 6
CD99 CD99 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CETN2 centrin, EF-hand protein, 2
CLDN10 claudin 10
COBLL1 cordon-bleu WH2 repeat protein-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DERL2 derlin 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
ERP44 endoplasmic reticulum protein 44
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FZD2 frizzled class receptor 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GMPPB GDP-mannose pyrophosphorylase B
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
MSMB microseminoprotein, beta-
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PHGDH phosphoglycerate dehydrogenase
PMP22 peripheral myelin protein 22
PPIB peptidylprolyl isomerase B (cyclophilin B)
RAD9A RAD9 homolog A (S. pombe)
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TBL1X transducin (beta)-like 1X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TRAM1 translocation associated membrane protein 1
TXNDC15 thioredoxin domain containing 15
UGDH UDP-glucose 6-dehydrogenase
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
AREG amphiregulin
BMP2 bone morphogenetic protein 2
CALML5 calmodulin-like 5
CCND1 cyclin D1
CD9 CD9 molecule
CTSW cathepsin W
CXADR coxsackie virus and adenovirus receptor
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F12 coagulation factor XII (Hageman factor)
FABP1 fatty acid binding protein 1, liver
FERMT1 fermitin family member 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPM6A glycoprotein M6A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
LMNA lamin A/C
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SATB2 SATB homeobox 2
SPRY2 sprouty homolog 2 (Drosophila)
TCF3 transcription factor 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
ZFP36L2 ZFP36 ring finger protein-like 2