BRD-K41859756_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K41859756_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANXA6 annexin A6
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FAM129A family with sequence similarity 129, member A
FKBP14 FK506 binding protein 14, 22 kDa
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL32 interleukin 32
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUCB2 nucleobindin 2
OAT ornithine aminotransferase
POU2AF1 POU class 2 associating factor 1
RAD9A RAD9 homolog A (S. pombe)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
CDC20 cell division cycle 20
CP ceruloplasmin (ferroxidase)
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
FABP4 fatty acid binding protein 4, adipocyte
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
HLF hepatic leukemia factor
IER3 immediate early response 3
KRT17 keratin 17, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MMP3 matrix metallopeptidase 3
NLRP2 NLR family, pyrin domain containing 2
NRN1 neuritin 1
NTS neurotensin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
TCTA T-cell leukemia translocation altered
TFF3 trefoil factor 3 (intestinal)
TOX3 TOX high mobility group box family member 3