BRD-K41845021_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K41845021_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADCK3 aarF domain containing kinase 3
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DIXDC1 DIX domain containing 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF3L eukaryotic translation initiation factor 3, subunit L
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IL6R interleukin 6 receptor
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MB myoglobin
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
NAP1L1 nucleosome assembly protein 1-like 1
NEBL nebulette
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAWR PRKC, apoptosis, WT1, regulator
PHGDH phosphoglycerate dehydrogenase
PNRC1 proline-rich nuclear receptor coactivator 1
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TBX3 T-box 3
TNS3 tensin 3
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
VGLL4 vestigial-like family member 4
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMAT3 zinc finger, matrin-type 3
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CMC2 C-x(9)-C motif containing 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPP4 dipeptidyl-peptidase 4
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FASTKD3 FAST kinase domains 3
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HOXB6 homeobox B6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPL17 mitochondrial ribosomal protein L17
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTTG1 pituitary tumor-transforming 1
RAB5C RAB5C, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLBP stem-loop binding protein
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein