BRD-K41220170_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

371 genes differentially expressed following the BRD-K41220170_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASPH aspartate beta-hydroxylase
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF115 chromosome 1 open reading frame 115
C1QB complement component 1, q subcomponent, B chain
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CALCOCO2 calcium binding and coiled-coil domain 2
CCDC68 coiled-coil domain containing 68
CCNG2 cyclin G2
CD163 CD163 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHI3L2 chitinase 3-like 2
CHMP1B charged multivesicular body protein 1B
CLEC3B C-type lectin domain family 3, member B
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPVL carboxypeptidase, vitellogenic-like
CRIP2 cysteine-rich protein 2
CTSA cathepsin A
CTSC cathepsin C
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOK4 docking protein 4
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FAM171A1 family with sequence similarity 171, member A1
FBXO2 F-box protein 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXG1 forkhead box G1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD6 FXYD domain containing ion transport regulator 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXD1 homeobox D1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IL13RA2 interleukin 13 receptor, alpha 2
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
ITM2C integral membrane protein 2C
KIF1A kinesin family member 1A
KIF5C kinesin family member 5C
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPXN leupaxin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MGST3 microsomal glutathione S-transferase 3
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MMP19 matrix metallopeptidase 19
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFASC neurofascin
NME7 NME/NM23 family member 7
NRCAM neuronal cell adhesion molecule
NTS neurotensin
NUAK1 NUAK family, SNF1-like kinase, 1
OAT ornithine aminotransferase
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PLS1 plastin 1
PLXND1 plexin D1
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RAB29 RAB29, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RRAGD Ras-related GTP binding D
RRAS related RAS viral (r-ras) oncogene homolog
RTN3 reticulon 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SIX1 SIX homeobox 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SNN stannin
SOX2 SRY (sex determining region Y)-box 2
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SRGN serglycin
SST somatostatin
STC1 stanniocalcin 1
STMN2 stathmin 2
STOM stomatin
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFE3 transcription factor binding to IGHM enhancer 3
TFPI2 tissue factor pathway inhibitor 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF20 transmembrane 4 L six family member 20
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
WWC3 WWC family member 3
YPEL5 yippee-like 5 (Drosophila)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BARD1 BRCA1 associated RING domain 1
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CD34 CD34 molecule
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
COMT catechol-O-methyltransferase
CRYAB crystallin, alpha B
CXCL11 chemokine (C-X-C motif) ligand 11
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCTD dCMP deaminase
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
DMD dystrophin
DPH2 DPH2 homolog (S. cerevisiae)
DSG3 desmoglein 3
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
EXOSC8 exosome component 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FHL2 four and a half LIM domains 2
FOXM1 forkhead box M1
FXN frataxin
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
GYG1 glycogenin 1
HDDC2 HD domain containing 2
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IL20RA interleukin 20 receptor, alpha
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
IVL involucrin
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MLPH melanophilin
MREG melanoregulin
MRPS30 mitochondrial ribosomal protein S30
MSMB microseminoprotein, beta-
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP88 nucleoporin 88kDa
NXT1 nuclear transport factor 2-like export factor 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALMD palmdelphin
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PHF11 PHD finger protein 11
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB25 RAB25, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RHCG Rh family, C glycoprotein
RPL10 ribosomal protein L10
S100A2 S100 calcium binding protein A2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SF3B3 splicing factor 3b, subunit 3, 130kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORD sorbitol dehydrogenase
SPAG7 sperm associated antigen 7
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STAG2 stromal antigen 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TMEM5 transmembrane protein 5
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
TSKU tsukushi, small leucine rich proteoglycan
TUBB tubulin, beta class I
UGCG UDP-glucose ceramide glucosyltransferase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein