BRD-K40645748_mefloquine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

30 genes differentially expressed following the BRD-K40645748_mefloquine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
CHI3L2 chitinase 3-like 2
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FZD7 frizzled class receptor 7
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI30 interferon, gamma-inducible protein 30
KRT15 keratin 15, type I
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
DKK3 dickkopf WNT signaling pathway inhibitor 3
GJA1 gap junction protein, alpha 1, 43kDa
LMO3 LIM domain only 3 (rhombotin-like 2)
NEBL nebulette
SDC1 syndecan 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFRC transferrin receptor
THBS2 thrombospondin 2
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)