BRD-K40373196_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K40373196_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CD86 CD86 molecule
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC7A C-type lectin domain family 7, member A
COL11A1 collagen, type XI, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHDDS dehydrodolichyl diphosphate synthase
DOK5 docking protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
FOXO3 forkhead box O3
FXYD6 FXYD domain containing ion transport regulator 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
KIAA0753 KIAA0753
KIAA1462 KIAA1462
KLF6 Kruppel-like factor 6
LRRC17 leucine rich repeat containing 17
LST1 leukocyte specific transcript 1
METTL7A methyltransferase like 7A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRKCH protein kinase C, eta
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A1 secretoglobin, family 2A, member 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
STC1 stanniocalcin 1
TMSB15A thymosin beta 15a
TRDV3 T cell receptor delta variable 3
TREM2 triggering receptor expressed on myeloid cells 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WISP2 WNT1 inducible signaling pathway protein 2
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
AKAP7 A kinase (PRKA) anchor protein 7
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BCLAF1 BCL2-associated transcription factor 1
BICD2 bicaudal D homolog 2 (Drosophila)
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COCH cochlin
COL9A3 collagen, type IX, alpha 3
CST1 cystatin SN
CST3 cystatin C
CST4 cystatin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EIF4A3 eukaryotic translation initiation factor 4A3
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FBXO11 F-box protein 11
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FMO5 flavin containing monooxygenase 5
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITGA6 integrin, alpha 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MALT1 MALT1 paracaspase
MAP2K6 mitogen-activated protein kinase kinase 6
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP7 matrix metallopeptidase 7
MSL1 male-specific lethal 1 homolog (Drosophila)
NEFL neurofilament, light polypeptide
NPTN neuroplastin
NRIP1 nuclear receptor interacting protein 1
PAX5 paired box 5
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PRKCA protein kinase C, alpha
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
QPCT glutaminyl-peptide cyclotransferase
RBP4 retinol binding protein 4, plasma
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAV1 salvador family WW domain containing protein 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK26 serine/threonine protein kinase 26
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOX3 TOX high mobility group box family member 3
TRIM29 tripartite motif containing 29
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta