BRD-K40329609_NCGC00184830-01_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K40329609_NCGC00184830-01_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
ATF5 activating transcription factor 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNE2 cyclin E2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
DCN decorin
DEFB1 defensin, beta 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM129A family with sequence similarity 129, member A
FAM3C family with sequence similarity 3, member C
FZD6 frizzled class receptor 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GLG1 golgi glycoprotein 1
GOLM1 golgi membrane protein 1
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HECA headcase homolog (Drosophila)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HP haptoglobin
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAG1 jagged 1
KDM5B lysine (K)-specific demethylase 5B
KLK8 kallikrein-related peptidase 8
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LEF1 lymphoid enhancer-binding factor 1
LRRC17 leucine rich repeat containing 17
LY96 lymphocyte antigen 96
MAGEA4 melanoma antigen family A4
MAGT1 magnesium transporter 1
MEIS2 Meis homeobox 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTSS1 metastasis suppressor 1
NID1 nidogen 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NRP1 neuropilin 1
PBX1 pre-B-cell leukemia homeobox 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REEP5 receptor accessory protein 5
RGS16 regulator of G-protein signaling 16
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
THSD7A thrombospondin, type I, domain containing 7A
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TWIST1 twist family bHLH transcription factor 1
VCAM1 vascular cell adhesion molecule 1
WLS wntless Wnt ligand secretion mediator
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CGA glycoprotein hormones, alpha polypeptide
CLIP2 CAP-GLY domain containing linker protein 2
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GRWD1 glutamate-rich WD repeat containing 1
GSTO1 glutathione S-transferase omega 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
LAT2 linker for activation of T cells family, member 2
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MRPS30 mitochondrial ribosomal protein S30
MSL1 male-specific lethal 1 homolog (Drosophila)
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
ODAM odontogenic, ameloblast asssociated
PARP2 poly (ADP-ribose) polymerase 2
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PROM1 prominin 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RELN reelin
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RRP1B ribosomal RNA processing 1B
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
TCERG1 transcription elongation regulator 1
TF transferrin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAPPC3 trafficking protein particle complex 3
TSC22D1 TSC22 domain family, member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF146 zinc finger protein 146
ZNF318 zinc finger protein 318