BRD-K40175214_torin-1_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

306 genes differentially expressed following the BRD-K40175214_torin-1_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANXA11 annexin A11
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
AXIN1 axin 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CLDN4 claudin 4
CPD carboxypeptidase D
CPM carboxypeptidase M
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSL cathepsin L
CYTH1 cytohesin 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF2 eukaryotic translation elongation factor 2
EFNA1 ephrin-A1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXOC1 exocyst complex component 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLG1 golgi glycoprotein 1
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
ICA1 islet cell autoantigen 1, 69kDa
IER3 immediate early response 3
IGBP1 immunoglobulin (CD79A) binding protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMB1 laminin, beta 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MLPH melanophilin
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MYO6 myosin VI
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PRKCH protein kinase C, eta
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RANBP2 RAN binding protein 2
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNF103 ring finger protein 103
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A2 solute carrier family 38, member 2
SOX9 SRY (sex determining region Y)-box 9
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYF2 SYF2 pre-mRNA-splicing factor
SYT17 synaptotagmin XVII
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP2 TIMP metallopeptidase inhibitor 2
TMC5 transmembrane channel-like 5
TOX3 TOX high mobility group box family member 3
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFAND5 zinc finger, AN1-type domain 5
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R2 cytochrome b5 reductase 2
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FADS2 fatty acid desaturase 2
FEN1 flap structure-specific endonuclease 1
FGA fibrinogen alpha chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMNB1 lamin B1
LMO4 LIM domain only 4
LTF lactotransferrin
LUM lumican
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NCAPG non-SMC condensin I complex, subunit G
NME1 NME/NM23 nucleoside diphosphate kinase 1
OIP5 Opa interacting protein 5
ORM1 orosomucoid 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PGC progastricsin (pepsinogen C)
PGRMC1 progesterone receptor membrane component 1
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSENEN presenilin enhancer gamma secretase subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN2 regulator of calcineurin 2
REEP1 receptor accessory protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SELT selenoprotein T
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TEX2 testis expressed 2
TF transferrin
TMEM47 transmembrane protein 47
TMPO thymopoietin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VBP1 von Hippel-Lindau binding protein 1
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein