BRD-K40175214_torin-1_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K40175214_torin-1_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BLNK B-cell linker
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COLEC12 collectin sub-family member 12
COMT catechol-O-methyltransferase
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DSG2 desmoglein 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENGASE endo-beta-N-acetylglucosaminidase
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
FOXO3 forkhead box O3
FRMD4B FERM domain containing 4B
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL18 interleukin 18
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB5 integrin, beta 5
KDM3A lysine (K)-specific demethylase 3A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LINC00342 long intergenic non-protein coding RNA 342
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MVP major vault protein
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OBSL1 obscurin-like 1
PBLD phenazine biosynthesis-like protein domain containing
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLTP phospholipid transfer protein
PLXNB2 plexin B2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REG3A regenerating islet-derived 3 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
SCRN1 secernin 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
VNN1 vanin 1
ZNF22 zinc finger protein 22
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C20ORF24 chromosome 20 open reading frame 24
CA2 carbonic anhydrase II
CALCA calcitonin-related polypeptide alpha
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CRYAB crystallin, alpha B
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
GREB1 growth regulation by estrogen in breast cancer 1
GYG1 glycogenin 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LBR lamin B receptor
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
STMN1 stathmin 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein