BRD-K40175214_torin-1_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K40175214_torin-1_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTN3A1 butyrophilin, subfamily 3, member A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN3 claudin 3
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COLEC12 collectin sub-family member 12
CPNE3 copine III
CTSA cathepsin A
DDR1 discoidin domain receptor tyrosine kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
ETFB electron-transfer-flavoprotein, beta polypeptide
FABP4 fatty acid binding protein 4, adipocyte
GAA glucosidase, alpha; acid
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST3H2A histone cluster 3, H2a
HS1BP3 HCLS1 binding protein 3
ICAM1 intercellular adhesion molecule 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAM3 junctional adhesion molecule 3
KCTD12 potassium channel tetramerization domain containing 12
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LAMA4 laminin, alpha 4
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPC1 Niemann-Pick disease, type C1
PECAM1 platelet/endothelial cell adhesion molecule 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLIN2 perilipin 2
PROS1 protein S (alpha)
RGS5 regulator of G-protein signaling 5
RSRP1 arginine/serine-rich protein 1
SELE selectin E
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
STXBP2 syntaxin binding protein 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VWF von Willebrand factor
WDR45 WD repeat domain 45
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALB albumin
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
CCND3 cyclin D3
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPU centromere protein U
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
EED embryonic ectoderm development
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXG1 forkhead box G1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LBR lamin B receptor
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MICU2 mitochondrial calcium uptake 2
MMP12 matrix metallopeptidase 12
MT1M metallothionein 1M
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SAP30 Sin3A-associated protein, 30kDa
SDF2L1 stromal cell-derived factor 2-like 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMC1A structural maintenance of chromosomes 1A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIGAR TP53 induced glycolysis regulatory phosphatase
TMPO thymopoietin
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB18 zinc finger and BTB domain containing 18