BRD-K40175214_torin-1_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K40175214_torin-1_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALR calreticulin
CDC5L cell division cycle 5-like
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHN1 chimerin 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST3 cystatin C
CXCR4 chemokine (C-X-C motif) receptor 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
EGR1 early growth response 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GTPBP8 GTP-binding protein 8 (putative)
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
LRRC16A leucine rich repeat containing 16A
MFAP3L microfibrillar-associated protein 3-like
MTMR11 myotubularin related protein 11
NID1 nidogen 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSG1 neuron specific gene family member 1
OPHN1 oligophrenin 1
PBX3 pre-B-cell leukemia homeobox 3
PNO1 partner of NOB1 homolog (S. cerevisiae)
PRKCI protein kinase C, iota
PTPRK protein tyrosine phosphatase, receptor type, K
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SET SET nuclear proto-oncogene
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SRRM2 serine/arginine repetitive matrix 2
SYBU syntabulin (syntaxin-interacting)
TBXA2R thromboxane A2 receptor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
C2CD2 C2 calcium-dependent domain containing 2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC5 chloride intracellular channel 5
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FDX1 ferredoxin 1
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GYG2 glycogenin 2
H2AFV H2A histone family, member V
HOPX HOP homeobox
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIAA0125 KIAA0125
LHFP lipoma HMGIC fusion partner
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PDLIM3 PDZ and LIM domain 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RGS3 regulator of G-protein signaling 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SCGB2A2 secretoglobin, family 2A, member 2
SFRP4 secreted frizzled-related protein 4
SH3BP4 SH3-domain binding protein 4
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC1 transforming, acidic coiled-coil containing protein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNC tenascin C
TPPP3 tubulin polymerization-promoting protein family member 3