BRD-K40175214_torin-1_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K40175214_torin-1_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACVR1B activin A receptor, type IB
ADM adrenomedullin
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTF3 basic transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAST calpastatin
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD24 CD24 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN1 chimerin 1
CP ceruloplasmin (ferroxidase)
CREBL2 cAMP responsive element binding protein-like 2
CRISP3 cysteine-rich secretory protein 3
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIAPH2 diaphanous-related formin 2
EFNA1 ephrin-A1
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EVL Enah/Vasp-like
FAXDC2 fatty acid hydroxylase domain containing 2
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATAD1 GATA zinc finger domain containing 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICA1 islet cell autoantigen 1, 69kDa
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBB inhibin, beta B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUND jun D proto-oncogene
KIAA0430 KIAA0430
KLHL24 kelch-like family member 24
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LOC399491
LTA4H leukotriene A4 hydrolase
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NPTX2 neuronal pentraxin II
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
OPTN optineurin
PABPC3 poly(A) binding protein, cytoplasmic 3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PHB2 prohibitin 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RNF130 ring finger protein 130
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS14P3 ribosomal protein S14 pseudogene 3
RSRP1 arginine/serine-rich protein 1
SCAMP1 secretory carrier membrane protein 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYF2 SYF2 pre-mRNA-splicing factor
SYT17 synaptotagmin XVII
TARBP1 TAR (HIV-1) RNA binding protein 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM140 transmembrane protein 140
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPN centromere protein N
CKS1B CDC28 protein kinase regulatory subunit 1B
CPM carboxypeptidase M
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FLRT2 fibronectin leucine rich transmembrane protein 2
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LMO4 LIM domain only 4
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPS12 mitochondrial ribosomal protein S12
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCAPD3 non-SMC condensin II complex, subunit D3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDX1 peroxiredoxin 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAC3D1 SAC3 domain containing 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIT2 slit homolog 2 (Drosophila)
TK1 thymidine kinase 1, soluble
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ZWINT ZW10 interacting kinetochore protein