BRD-K40175214_torin-1_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K40175214_torin-1_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CD52 CD52 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CHGB chromogranin B
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMP1 epithelial membrane protein 1
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA1 high mobility group AT-hook 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
JAK1 Janus kinase 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLHL21 kelch-like family member 21
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDE4DIP phosphodiesterase 4D interacting protein
PLAU plasminogen activator, urokinase
POU2AF1 POU class 2 associating factor 1
PSD3 pleckstrin and Sec7 domain containing 3
RBP4 retinol binding protein 4, plasma
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ASPN asporin
ATP11B ATPase, class VI, type 11B
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
CHSY1 chondroitin sulfate synthase 1
CLU clusterin
CXCL10 chemokine (C-X-C motif) ligand 10
EDRF1 erythroid differentiation regulatory factor 1
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL5 ELOVL fatty acid elongase 5
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXOSC4 exosome component 4
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IDO1 indoleamine 2,3-dioxygenase 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
LRRC17 leucine rich repeat containing 17
PEX11A peroxisomal biogenesis factor 11 alpha
PEX3 peroxisomal biogenesis factor 3
PRDX2 peroxiredoxin 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOCS1 suppressor of cytokine signaling 1
TFAM transcription factor A, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN12 tetraspanin 12
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)