BRD-K40175214_torin-1_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K40175214_torin-1_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AHNAK AHNAK nucleoprotein
ANKRD28 ankyrin repeat domain 28
ANKRD36B ankyrin repeat domain 36B
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASPN asporin
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CPD carboxypeptidase D
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
DMTF1 cyclin D binding myb-like transcription factor 1
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FST follistatin
G0S2 G0/G1 switch 2
GBP2 guanylate binding protein 2, interferon-inducible
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HTRA1 HtrA serine peptidase 1
ICAM2 intercellular adhesion molecule 2
IGF1R insulin-like growth factor 1 receptor
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
ITGAV integrin, alpha V
KLF9 Kruppel-like factor 9
LMO4 LIM domain only 4
LPIN1 lipin 1
LPL lipoprotein lipase
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NRCAM neuronal cell adhesion molecule
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
POSTN periostin, osteoblast specific factor
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPARCL1 SPARC-like 1 (hevin)
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNS3 tensin 3
TRAM2 translocation associated membrane protein 2
TRPS1 trichorhinophalangeal syndrome I
VWF von Willebrand factor
WDR19 WD repeat domain 19
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOD apolipoprotein D
ATP10B ATPase, class V, type 10B
C2CD2 C2 calcium-dependent domain containing 2
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DYNLT3 dynein, light chain, Tctex-type 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GSPT2 G1 to S phase transition 2
IGFBP6 insulin-like growth factor binding protein 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
MYLK myosin light chain kinase
NELL2 NEL-like 2 (chicken)
NKX3-1 NK3 homeobox 1
PARM1 prostate androgen-regulated mucin-like protein 1
PIP prolactin-induced protein
PLCB4 phospholipase C, beta 4
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
SLC44A4 solute carrier family 44, member 4
TESC tescalcin
TM9SF3 transmembrane 9 superfamily member 3
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8