BRD-K40175214_torin-1_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K40175214_torin-1_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP68 centrosomal protein 68kDa
CHN1 chimerin 1
CLCN3 chloride channel, voltage-sensitive 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTSL cathepsin L
CXCR4 chemokine (C-X-C motif) receptor 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
E2F2 E2F transcription factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF4B eukaryotic translation initiation factor 4B
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM13A family with sequence similarity 13, member A
FAM60A family with sequence similarity 60, member A
FAR2 fatty acyl CoA reductase 2
GALC galactosylceramidase
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC399491
LXN latexin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MMP11 matrix metallopeptidase 11
MSLN mesothelin
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OFD1 oral-facial-digital syndrome 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PLSCR4 phospholipid scramblase 4
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL4 ribosomal protein L4
RSL24D1 ribosomal L24 domain containing 1
SEPW1 selenoprotein W, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP4 secreted frizzled-related protein 4
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGIF1 TGFB-induced factor homeobox 1
THBS3 thrombospondin 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALOX15B arachidonate 15-lipoxygenase, type B
ARG2 arginase 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BLNK B-cell linker
BPIFA1 BPI fold containing family A, member 1
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK1 checkpoint kinase 1
CKB creatine kinase, brain
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
CPE carboxypeptidase E
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FAM129A family with sequence similarity 129, member A
FGFBP1 fibroblast growth factor binding protein 1
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
IDO1 indoleamine 2,3-dioxygenase 1
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
MALL mal, T-cell differentiation protein-like
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARM1 prostate androgen-regulated mucin-like protein 1
PBK PDZ binding kinase
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLEK pleckstrin
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
SC5D sterol-C5-desaturase
SHCBP1 SHC SH2-domain binding protein 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPAG5 sperm associated antigen 5
SPINK5 serine peptidase inhibitor, Kazal type 5
TTK TTK protein kinase