BRD-K40175214_torin-1_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARID5B AT rich interactive domain 5B (MRF1-like)
BMP2 bone morphogenetic protein 2
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNG1 cyclin G1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEMIP cell migration inducing protein, hyaluronan binding
CTGF connective tissue growth factor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR1 fibroblast growth factor receptor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FST follistatin
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
JMJD1C jumonji domain containing 1C
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
KIF5C kinesin family member 5C
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
OXTR oxytocin receptor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PTN pleiotrophin
RPL22 ribosomal protein L22
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELE selectin E
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
C1S complement component 1, s subcomponent
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL1 four and a half LIM domains 1
FKBP4 FK506 binding protein 4, 59kDa
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
MAT2A methionine adenosyltransferase II, alpha
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PPIF peptidylprolyl isomerase F
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TMSB15A thymosin beta 15a
XIST X inactive specific transcript (non-protein coding)