BRD-K40175214_torin-1_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

193 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
AMOTL2 angiomotin like 2
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ARG1 arginase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAMLG calcium modulating ligand
CCND1 cyclin D1
CCNG2 cyclin G2
CD14 CD14 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EIF3F eukaryotic translation initiation factor 3, subunit F
F13A1 coagulation factor XIII, A1 polypeptide
FGF9 fibroblast growth factor 9
GAB2 GRB2-associated binding protein 2
GLG1 golgi glycoprotein 1
GRN granulin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LINC00341 long intergenic non-protein coding RNA 341
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MN1 meningioma (disrupted in balanced translocation) 1
MNT MAX network transcriptional repressor
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NCOR2 nuclear receptor corepressor 2
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PLA2G16 phospholipase A2, group XVI
PODXL podocalyxin-like
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STAB1 stabilin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TM4SF1 transmembrane 4 L six family member 1
TMPRSS3 transmembrane protease, serine 3
TSPAN6 tetraspanin 6
TXNIP thioredoxin interacting protein
VCAN versican
WDR13 WD repeat domain 13
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADRB2 adrenoceptor beta 2, surface
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
H2AFV H2A histone family, member V
HK2 hexokinase 2
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHCBP1 SHC SH2-domain binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SRGN serglycin
STRA13 stimulated by retinoic acid 13
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TUBG1 tubulin, gamma 1
VEGFA vascular endothelial growth factor A
WBSCR22 Williams Beuren syndrome chromosome region 22
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein