BRD-K40175214_torin-1_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-K40175214_torin-1_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BPHL biphenyl hydrolase-like (serine hydrolase)
BSG basigin (Ok blood group)
C6ORF48 chromosome 6 open reading frame 48
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CRISP3 cysteine-rich secretory protein 3
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG2 desmoglein 2
DSP desmoplakin
DST dystonin
DUSP4 dual specificity phosphatase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
FAXDC2 fatty acid hydroxylase domain containing 2
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
GDI1 GDP dissociation inhibitor 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF6 interferon regulatory factor 6
KDM5B lysine (K)-specific demethylase 5B
KRT17 keratin 17, type I
LAGE3 L antigen family, member 3
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP1 matrix metallopeptidase 1
MRC2 mannose receptor, C type 2
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
PLAGL1 pleiomorphic adenoma gene-like 1
PRDX2 peroxiredoxin 2
PTHLH parathyroid hormone-like hormone
RALGDS ral guanine nucleotide dissociation stimulator
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
S100A7 S100 calcium binding protein A7
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38L serine/threonine kinase 38 like
TERT telomerase reverse transcriptase
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNNT1 troponin T type 1 (skeletal, slow)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AGTR1 angiotensin II receptor, type 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BORA bora, aurora kinase A activator
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF24 chromosome 20 open reading frame 24
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COASY CoA synthase
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EAPP E2F-associated phosphoprotein
EMP2 epithelial membrane protein 2
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXM1 forkhead box M1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HJURP Holliday junction recognition protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRX5 iroquois homeobox 5
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1BP1 integrin beta 1 binding protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JCHAIN joining chain of multimeric IgA and IgM
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NRGN neurogranin (protein kinase C substrate, RC3)
NUP93 nucleoporin 93kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD51C RAD51 paralog C
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
THAP11 THAP domain containing 11
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WFDC2 WAP four-disulfide core domain 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)