BRD-K40175214_torin-1_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K40175214_torin-1_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
AQP3 aquaporin 3 (Gill blood group)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CST1 cystatin SN
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DST dystonin
DUSP10 dual specificity phosphatase 10
EDN1 endothelin 1
EIF3D eukaryotic translation initiation factor 3, subunit D
ENO2 enolase 2 (gamma, neuronal)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCMR Fc fragment of IgM receptor
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100272216 uncharacterized LOC100272216
LPIN2 lipin 2
LPXN leupaxin
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCA protein kinase C, alpha
PXDC1 PX domain containing 1
RB1CC1 RB1-inducible coiled-coil 1
REG1A regenerating islet-derived 1 alpha
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
SERINC5 serine incorporator 5
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANK2 ankyrin 2, neuronal
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
AURKB aurora kinase B
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CETN2 centrin, EF-hand protein, 2
CHEK2 checkpoint kinase 2
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GSTP1 glutathione S-transferase pi 1
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LTF lactotransferrin
LUM lumican
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SQLE squalene epoxidase
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR3A torsin family 3, member A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C