BRD-K40175214_torin-1_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K40175214_torin-1_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
AMOTL2 angiomotin like 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
ARID5B AT rich interactive domain 5B (MRF1-like)
BGN biglycan
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CBX1 chromobox homolog 1
CCNF cyclin F
CD200 CD200 molecule
CD8A CD8a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLMN calmin (calponin-like, transmembrane)
COL5A2 collagen, type V, alpha 2
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EDN1 endothelin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXG1 forkhead box G1
FZD4 frizzled class receptor 4
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
IER5 immediate early response 5
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
KIAA0355 KIAA0355
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
PLK2 polo-like kinase 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SULF1 sulfatase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMSB15A thymosin beta 15a
VNN1 vanin 1
WEE1 WEE1 G2 checkpoint kinase
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CFH complement factor H
CLU clusterin
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENO1 enolase 1, (alpha)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FKBP14 FK506 binding protein 14, 22 kDa
GARS glycyl-tRNA synthetase
GPX3 glutathione peroxidase 3
GYG1 glycogenin 1
HMOX1 heme oxygenase 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LPIN1 lipin 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MARS methionyl-tRNA synthetase
METTL7A methyltransferase like 7A
MX2 MX dynamin-like GTPase 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NUPR1 nuclear protein, transcriptional regulator, 1
OSMR oncostatin M receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PSAT1 phosphoserine aminotransferase 1
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
REXO2 RNA exonuclease 2
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG4 sperm associated antigen 4
SRPRB signal recognition particle receptor, B subunit
STC1 stanniocalcin 1
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM100 transmembrane protein 100
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WDR61 WD repeat domain 61
YARS tyrosyl-tRNA synthetase