BRD-K40175214_torin-1_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

146 genes differentially expressed following the BRD-K40175214_torin-1_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CCDC28A coiled-coil domain containing 28A
CD14 CD14 molecule
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM114A1 family with sequence similarity 114, member A1
FOXO4 forkhead box O4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
ISG20 interferon stimulated exonuclease gene 20kDa
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NUSAP1 nucleolar and spindle associated protein 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB13 RAB13, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TXNIP thioredoxin interacting protein
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACP5 acid phosphatase 5, tartrate resistant
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AK4 adenylate kinase 4
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BMP2 bone morphogenetic protein 2
BZW2 basic leucine zipper and W2 domains 2
CCDC86 coiled-coil domain containing 86
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CIAPIN1 cytokine induced apoptosis inhibitor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSE cathepsin E
CYCS cytochrome c, somatic
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GGCT gamma-glutamylcyclotransferase
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP8 GTP-binding protein 8 (putative)
HAT1 histone acetyltransferase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HN1 hematological and neurological expressed 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF5 Kruppel-like factor 5 (intestinal)
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCH2 mitochondrial carrier 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP56 NOP56 ribonucleoprotein
NPTX2 neuronal pentraxin II
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRDX2 peroxiredoxin 2
PRNP prion protein
PRSS3 protease, serine, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
SFN stratifin
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
VIM vimentin
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon