BRD-K40175214_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K40175214_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
BRD2 bromodomain containing 2
CADM1 cell adhesion molecule 1
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
EAPP E2F-associated phosphoprotein
FABP7 fatty acid binding protein 7, brain
FNDC3B fibronectin type III domain containing 3B
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
KLF6 Kruppel-like factor 6
LPIN1 lipin 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PADI2 peptidyl arginine deiminase, type II
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PRAME preferentially expressed antigen in melanoma
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
B3GNT1
C20ORF24 chromosome 20 open reading frame 24
CA2 carbonic anhydrase II
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKB creatine kinase, brain
COG2 component of oligomeric golgi complex 2
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
DEGS1 delta(4)-desaturase, sphingolipid 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALE UDP-galactose-4-epimerase
GAS2L1 growth arrest-specific 2 like 1
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGKV1-5 immunoglobulin kappa variable 1-5
MREG melanoregulin
MYH10 myosin, heavy chain 10, non-muscle
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PRDX4 peroxiredoxin 4
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RPIA ribose 5-phosphate isomerase A
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
TFDP1 transcription factor Dp-1
THAP11 THAP domain containing 11
VDAC3 voltage-dependent anion channel 3