BRD-K39987650_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

344 genes differentially expressed following the BRD-K39987650_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AKAP8L A kinase (PRKA) anchor protein 8-like
ALAS2 5'-aminolevulinate synthase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANKRD12 ankyrin repeat domain 12
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATXN1 ataxin 1
AZU1 azurocidin 1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST6 cystatin E/M
CTGF connective tissue growth factor
CUX1 cut-like homeobox 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FBXL12 F-box and leucine-rich repeat protein 12
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FTL ferritin, light polypeptide
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL13RA2 interleukin 13 receptor, alpha 2
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KAT6A K(lysine) acetyltransferase 6A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0907 KIAA0907
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LPIN2 lipin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL1 muscleblind-like splicing regulator 1
MED13 mediator complex subunit 13
MIR22HG MIR22 host gene
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
N4BP2L2 NEDD4 binding protein 2-like 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH3 notch 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
NXF1 nuclear RNA export factor 1
OPN3 opsin 3
OSBPL3 oxysterol binding protein-like 3
OSR2 odd-skipped related transciption factor 2
PAWR PRKC, apoptosis, WT1, regulator
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
PSPC1 paraspeckle component 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PUM1 pumilio RNA-binding family member 1
QKI QKI, KH domain containing, RNA binding
RAB7A RAB7A, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSL1D1 ribosomal L1 domain containing 1
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SERINC1 serine incorporator 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHROOM2 shroom family member 2
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPEN spen family transcriptional repressor
SRGN serglycin
STK17A serine/threonine kinase 17a
STOM stomatin
STX3 syntaxin 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TBPL1 TBP-like 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TNPO1 transportin 1
TNS1 tensin 1
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBE2E1 ubiquitin-conjugating enzyme E2E 1
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHNAK2 AHNAK nucleoprotein 2
AKAP7 A kinase (PRKA) anchor protein 7
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANPEP alanyl (membrane) aminopeptidase
ARHGAP1 Rho GTPase activating protein 1
ASL argininosuccinate lyase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C21ORF33 chromosome 21 open reading frame 33
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CAT catalase
CCDC53 coiled-coil domain containing 53
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CES2 carboxylesterase 2
CETN2 centrin, EF-hand protein, 2
CHRDL1 chordin-like 1
COL8A2 collagen, type VIII, alpha 2
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHFR dihydrofolate reductase
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DZIP3 DAZ interacting zinc finger protein 3
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ETFB electron-transfer-flavoprotein, beta polypeptide
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FAM173A family with sequence similarity 173, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCAT glycine C-acetyltransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMDS GDP-mannose 4,6-dehydratase
HADH hydroxyacyl-CoA dehydrogenase
ICAM3 intercellular adhesion molecule 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM5 minichromosome maintenance complex component 5
MRPL15 mitochondrial ribosomal protein L15
MRPL16 mitochondrial ribosomal protein L16
MRPL40 mitochondrial ribosomal protein L40
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTIF2 mitochondrial translational initiation factor 2
NBN nibrin
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NMI N-myc (and STAT) interactor
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPR3 natriuretic peptide receptor 3
NUBPL nucleotide binding protein-like
NUP37 nucleoporin 37kDa
ORC3 origin recognition complex, subunit 3
PCYOX1L prenylcysteine oxidase 1 like
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RFC4 replication factor C (activator 1) 4, 37kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RMDN1 regulator of microtubule dynamics 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SIRT5 sirtuin 5
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBP STAM binding protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D16 TBC1 domain family, member 16
TCEA2 transcription elongation factor A (SII), 2
TGM1 transglutaminase 1
THYN1 thymocyte nuclear protein 1
TMEM97 transmembrane protein 97
TRIM14 tripartite motif containing 14
TST thiosulfate sulfurtransferase (rhodanese)
TSTA3 tissue specific transplantation antigen P35B
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
UBL4A ubiquitin-like 4A
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WDR61 WD repeat domain 61
WFS1 Wolfram syndrome 1 (wolframin)
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF32 zinc finger protein 32
ZWINT ZW10 interacting kinetochore protein