BRD-K39944607_32937_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K39944607_32937_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
API5 apoptosis inhibitor 5
AQP3 aquaporin 3 (Gill blood group)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CREBL2 cAMP responsive element binding protein-like 2
CSNK1E casein kinase 1, epsilon
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
DSP desmoplakin
FAM129A family with sequence similarity 129, member A
FGL2 fibrinogen-like 2
FHOD3 formin homology 2 domain containing 3
GAL galanin/GMAP prepropeptide
GPX3 glutathione peroxidase 3
HIC2 hypermethylated in cancer 2
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGL immunoglobulin lambda locus
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOR loricrin
LYPD3 LY6/PLAUR domain containing 3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MYOF myoferlin
PCDH7 protocadherin 7
PECR peroxisomal trans-2-enoyl-CoA reductase
PERP PERP, TP53 apoptosis effector
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
TCEA2 transcription elongation factor A (SII), 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM45A transmembrane protein 45A
TUBB2A tubulin, beta 2A class IIa
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
AGR2 anterior gradient 2
AK1 adenylate kinase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMDHD2 amidohydrolase domain containing 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
C9ORF3 chromosome 9 open reading frame 3
CIRBP cold inducible RNA binding protein
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDF1 endothelial differentiation-related factor 1
ELOVL6 ELOVL fatty acid elongase 6
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALE UDP-galactose-4-epimerase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPI glucose-6-phosphate isomerase
GPX1 glutathione peroxidase 1
H1F0 H1 histone family, member 0
HNRNPL heterogeneous nuclear ribonucleoprotein L
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD5 potassium channel tetramerization domain containing 5
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF2 Kruppel-like factor 2
KRT13 keratin 13, type I
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PENK proenkephalin
PGC progastricsin (pepsinogen C)
PGD phosphogluconate dehydrogenase
PLAU plasminogen activator, urokinase
PNKP polynucleotide kinase 3'-phosphatase
PRAF2 PRA1 domain family, member 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS11 ribosomal protein S11
SCAND1 SCAN domain containing 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRRM2 serine/arginine repetitive matrix 2
SRSF6 serine/arginine-rich splicing factor 6
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TPM2 tropomyosin 2 (beta)
UBE2A ubiquitin-conjugating enzyme E2A
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
ZBTB18 zinc finger and BTB domain containing 18