BRD-K39746403_ERYTHROMYCIN ESTOLATE_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K39746403_ERYTHROMYCIN ESTOLATE_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP1 A kinase (PRKA) anchor protein 1
ALG8 ALG8, alpha-1,3-glucosyltransferase
BTG2 BTG family, member 2
C14ORF1 chromosome 14 open reading frame 1
CCND2 cyclin D2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLCA2 chloride channel accessory 2
CLNS1A chloride channel, nucleotide-sensitive, 1A
COL10A1 collagen, type X, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK11 kallikrein-related peptidase 11
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MMP11 matrix metallopeptidase 11
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
RNASE6 ribonuclease, RNase A family, k6
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TP63 tumor protein p63
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
BZW2 basic leucine zipper and W2 domains 2
CCL5 chemokine (C-C motif) ligand 5
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COL9A3 collagen, type IX, alpha 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
KANK1 KN motif and ankyrin repeat domains 1
MGP matrix Gla protein
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDE8B phosphodiesterase 8B
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
RHOBTB3 Rho-related BTB domain containing 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2