BRD-K39687892_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

292 genes differentially expressed following the BRD-K39687892_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTN1 actinin, alpha 1
AGR2 anterior gradient 2
AIF1 allograft inflammatory factor 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF115 chromosome 1 open reading frame 115
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
COL1A1 collagen, type I, alpha 1
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP1 cellular retinoic acid binding protein 1
CRIP2 cysteine-rich protein 2
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK4 docking protein 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FAM102A family with sequence similarity 102, member A
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRN granulin
GSN gelsolin
HEBP1 heme binding protein 1
HEPH hephaestin
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
KLF10 Kruppel-like factor 10
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LITAF lipopolysaccharide-induced TNF factor
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MFAP2 microfibrillar-associated protein 2
MFSD10 major facilitator superfamily domain containing 10
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLK2 polo-like kinase 2
POR P450 (cytochrome) oxidoreductase
PPAP2C phosphatidic acid phosphatase type 2C
PRAF2 PRA1 domain family, member 2
PRSS8 protease, serine, 8
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEPHS2 selenophosphate synthetase 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFE3 transcription factor binding to IGHM enhancer 3
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF20 transmembrane 4 L six family member 20
TMSB15A thymosin beta 15a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BARD1 BRCA1 associated RING domain 1
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
C1ORF116 chromosome 1 open reading frame 116
CCNA2 cyclin A2
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPM centromere protein M
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
COBLL1 cordon-bleu WH2 repeat protein-like 1
COMT catechol-O-methyltransferase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUT deoxyuridine triphosphatase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GSTZ1 glutathione S-transferase zeta 1
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
ING3 inhibitor of growth family, member 3
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KIF15 kinesin family member 15
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MSRA methionine sulfoxide reductase A
NAV3 neuron navigator 3
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NPEPL1 aminopeptidase-like 1
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
RAD51AP1 RAD51 associated protein 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RFC3 replication factor C (activator 1) 3, 38kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCEL sciellin
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SMC2 structural maintenance of chromosomes 2
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SRSF7 serine/arginine-rich splicing factor 7
STXBP6 syntaxin binding protein 6 (amisyn)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TDP1 tyrosyl-DNA phosphodiesterase 1
TENM1 teneurin transmembrane protein 1
TIMELESS timeless circadian clock
TMEM47 transmembrane protein 47
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TTN titin
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein