BRD-K39580048_arg-a1-2 BRD-K39580048_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K39580048_arg-a1-2 BRD-K39580048_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BMP2 bone morphogenetic protein 2
C9ORF3 chromosome 9 open reading frame 3
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDND1 claudin domain containing 1
CTSW cathepsin W
DUSP10 dual specificity phosphatase 10
DYNLT3 dynein, light chain, Tctex-type 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IL2RG interleukin 2 receptor, gamma
IRF1 interferon regulatory factor 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0226L KIAA0226-like
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LAMC2 laminin, gamma 2
LPAR1 lysophosphatidic acid receptor 1
LRRN3 leucine rich repeat neuronal 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1F metallothionein 1F
MT1X metallothionein 1X
NEFM neurofilament, medium polypeptide
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB4 phospholipase C, beta 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRF1 perforin 1 (pore forming protein)
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
RGS4 regulator of G-protein signaling 4
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100B S100 calcium binding protein B
SC5D sterol-C5-desaturase
SCG5 secretogranin V
SCRG1 stimulator of chondrogenesis 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SPRR1A small proline-rich protein 1A
SQSTM1 sequestosome 1
STMN2 stathmin 2
TARP TCR gamma alternate reading frame protein
TFPI2 tissue factor pathway inhibitor 2
TRD T cell receptor delta locus
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
TXNRD1 thioredoxin reductase 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ASB13 ankyrin repeat and SOCS box containing 13
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAST calpastatin
CCDC86 coiled-coil domain containing 86
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN2A cyclin-dependent kinase inhibitor 2A
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC3B C-type lectin domain family 3, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DBN1 drebrin 1
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F13A1 coagulation factor XIII, A1 polypeptide
FGFR4 fibroblast growth factor receptor 4
FXYD2 FXYD domain containing ion transport regulator 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLDC glycine dehydrogenase (decarboxylating)
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H2BG histone cluster 1, H2bg
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
ISYNA1 inositol-3-phosphate synthase 1
KAZN kazrin, periplakin interacting protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MFAP5 microfibrillar associated protein 5
MLANA melan-A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MXRA5 matrix-remodelling associated 5
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
PBX3 pre-B-cell leukemia homeobox 3
PDGFD platelet derived growth factor D
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SALL2 spalt-like transcription factor 2
SASH1 SAM and SH3 domain containing 1
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
UBE2G2 ubiquitin-conjugating enzyme E2G 2
VAT1 vesicle amine transport 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1